Tuesday, February 14, 2017

My New LCHF Dyslipidemia Hypothesis

Once again, I have to thank Rhonda Patrick from Found My Fitness for presenting some fascinating information.  In her podcast titled "Does Saturated Fat Cause Heart Disease?" she lays out an argument that some people with a specific genetic polymorphism may be better off by consuming more polyunsaturated fats (PUFA) and less saturated fats.  The polymorphism in question has to do with the fat mass and obesity-associated protein (FTO).  Using her free genetics tool and my raw data from 23andme, I have learned that I have genetic variants that influence my genetic obesity and diabetes risk in the following ways (quoted text from her genetic report):

  • Increasing my risk of obesity by 1.3 fold "due to a shift from energy-burning adipocytes (brown adipose tissue) to energy-storing adipocytes (white adipose tissue). This results in adipocytes storing more lipids and more body-weight gain. In addition, this genotype is associated with reduced thermogenesis (the burning of fat to produce heat) in response to cold exposure and this genotype and may result in less fat burning in adipose tissue during cold exposure."
  • Increasing my risk of obesity by 1.67 fold "particularly in the context of a high saturated fat and low polyunsaturated fat intake."
  • "An intermediate increased risk of obesity and type 2 diabetes due to high production of ghrelin. Higher ghrelin levels are associated with over-eating due to lack of satiation."
  • "Saturated fat may have a negative effect on blood glucose and insulin levels and increases type 2 diabetes risk."
Having heard this new information, I am going to develop a new LCHF and lifestyle regimen to see if I can further reduce my blood lipids.  For background, using a LCHF nutrition protocol and increased physical activity, I have been able to bring my T2DM and sleep apnea under control and I have improved my blood lipids without the use of cholesterol lowering medications.  That said, my lipids are still not ideal.

Armed with this new information, I will take the following steps for a 4 week period:
  • Substitute PUFAs for saturated fats
    • Increase my consumption of fatty fish
    • Replace farmed meat with lean game meat
    • Replace butter with olive oil and avocado oil
    • Supplement with fish oil daily
  • Increase brown adipose tissue
    • Increase cold water exposure
    • Reduce my covering while sleeping to a sheet or one thin blanket
  • Maintain my current level of physical activity
Once I have completed this 4-week trial, I will then conduct a NMR lipoprotein profile to see what changes occur.  Once I have the data, I will post an update.

2 comments:

  1. David, where do you get your blood work done?

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    1. I get as much done through my insurance as is covered. I coordinate that with my primary care physician. For anything not covered, I will check the price at the place where I am going for my covered tests and see what the retail cost is for the tests. I compare those prices to the prices I find at requestatest.com. If they are comparable I will just pay for them along with my other testing. If Request a Test has a better price, I go with them. Request a Test offers testing through Quest or Labcorp.

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